Black Cumin: A Review of its Pharmacological Effects and its Main Active Constituent

Pharmacognosy Reviews,2022,16,32,107-125.
Published:August 2022
Type:Review Article
Author(s) affiliations:

Jean Noël Nyemb1, Hazem Shaheen2, Lamiaa Wasef2, Richard Nyamota3, Narimane Segueni4,5, Gaber El-Saber Batiha2,*

1Department of Refining and Petrochemistry, National Advanced School of Mines and Petroleum Industries, University of Maroua, Kaele, CAMEROON.

2Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, EGYPT.

3Department of Biochemistry and Molecular Biology, Faculty of Science, Egerton University, Egerton, KENYA.

4Laboratory of Natural Product and Organic Synthesis, Department of Chemistry, Faculty of Exact science, University Constantine 1. Constantine, ALGERIA.

5Faculty of Medicine, University Salah Boubnider Constantine 3, Constantine, ALGERIA.


Black cumin (Nigella sativa) is a well-known medicinal plant and the most exhaustively exploited species of Ranunculaceae family. Nigella sativa seeds have been extensively used as spice in Middle Eastern and Indian cuisine. In addition, they have a long history of use in medicine. This review described the pharmacognostical characteristics, traditional applications and health benefits of N. sativa. The review also described the phytochemical composition and pharmacological properties of N. sativa and its bioactive constituents, in particular thymoquinone, the most abundant active constituent responsible of the effectiveness and pharmacological properties of N. sativa. The review also enumerates pharmacokinetics, possible interaction caused by co-administered drugs, daily dose consumption and toxicity of this medicinal plant. These make the use of N. sativa an interesting approach to the development of new adjuvant or complement treatment.

Cite This Article

Vancouver Style ::
J. Noël Nyemb, Shaheen, H. , Wasef, L. , Nyamota, R. , Segueni, N. , and Batiha, G. El- Saber, Black Cumin: A Review of its Pharmacological Effects and its Main Active Constituent, Pharmacognosy Reviews, vol. 16, no. 32, pp. 107-125, 2022.