Effects of Mucuna pruriens (L.) Supplementation on Experimental Models of Parkinson's Disease: A Systematic Review

Introduction: Mucuna pruriens (L.)DC. (Mp) has been used in the treatment of numerous diseases in Indian Ayurvedic medicine, mainly for delaying the symptoms of Parkinson's disease (PD), and has as its main component levodopa (L-DOPA). The aim of this work is to systematically review the effects of Mp supplementation on experimental models of PD due to its neuroprotective and antioxidant properties. Materials and Methods: The search was conducted through PubMed, ScienceDirect, Cochrane Library, and Scientific Electronic Library Online databases, where a number of relevant articles were found. Results: Mp demonstrated significant positive responses in the experimental models of PD by improving motor deficits and by enhancing the activity of the antioxidant systems, reducing oxidative stress. In addition, it presented some advantages when compared to a conventional antiparkinsonian drug as it minimized the occurrence and severity of dyskinesias. Conclusion: Thus, considering that the use of herbal medicines decreases the likelihood of side effects associated with the pharmaceutical drugs, this work aims to summarize and evaluate the data available regarding the mechanism of action of Mp and the reported benefits of this plant as an alternative to improve the quality of life of individuals with PD.