Cholinesterase Inhibitors from Botanicals

Pharmacognosy Review,2013,7,14,121-130.
Published:October 2013
Type:Review Article
Author(s) affiliations:

Faiyaz Ahmed1, Raza Murad Ghalib2, P Sasikala1, KK Mueen Ahmed3

1Indian Institute of Crop Processing Technology, Ministry of Food Processing Industries, Government of India, Thanjavur, INDIA.

2Department of Chemistry, Kulliyyah of Science, IIUM, Kuantan, Malaysia 3 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Kingdom of SAUDI ARABIA.


Alzheimer's disease (AD) is a progressive neurodegenerative disease, wherein a progressive loss of cholinergic synapses occurs in hippocampus and neocortex. Decreased concentration of the neurotransmitter, acetylcholine (ACh), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat AD and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Consequently, researches have focused their attention towards finding cholinesterase inhibitors from natural products. A large number of such inhibitors have been isolated from medicinal plants. This review presents a comprehensive account of the advances in field of cholinesterase inhibitor phytoconstituents. The structures of some important phytoconstituents (collected through are also presented and the scope for future research is discussed.

Cite This Article

Vancouver Style ::
F. Ahmed, Ghalib, R. Murad, Sasikala, P. , and Ahmed, K. K. Mueen, Cholinesterase Inhibitors from Botanicals, Pharmacognosy Review, vol. 7, no. 14, pp. 121-130, 2013.