In vitro Antitumor Effect on Melanoma Cell Line and Chemical Composition of Diplopterys pubipetala (A. Juss) W.R. Anderson and C. Davis

Pharmacognosy Reviews,2021,14,28,146-154.
Published:February 2021
Type:Original Article
Authors:
Author(s) affiliations:

Kamylla Teixeira Santos1, Ludmilla Regina Souza2, Alfredo Mauricio Batista de Paula2, Clarice Avelar Almeida1, Dario Alves de Oliveira1, Afrânio Farias de Melo Júnior1, Elytania Veiga Menezes1, Murilo Malveira Brandão1, Vanessa de Andrade Royo1,*

1Department of Geral Biology, Postgraduate Program in Biotechnology, State University of Montes Claros, Laboratory of Natural Products, Montes Claros, Minas Gerais, BRAZIL.

2Department of Odontology, Postgraduate Program in Health Sciences, State University of Montes Claros, Health Research Laboratory, Montes Claros, Minas Gerais, BRAZIL.

Abstract:

The Banisteriopsis pubipetala A. Juss. came to be considered synonymous with Diplopterys pubipetala (A. Juss.) W.R. Anderson and C. Davis. D. pubipetala is a liana, occurring in the cerrado biome, belonging to a genus already described in the literature for the antioxidant action of some species and for being effective in controlling some types of cancer, including cutaneous melanoma, which is the most common malignant tumor in the whole human species. However, D. pubipetala is still poorly studied with regard to bioactive potential and chemical composition. The main objective of the work is to evaluate antitumor activity by evaluating migratory activity, detecting cell death and determining cell viability of the partitions and fractions of D. pubipetala leaf and stem. The fractions demonstrated the ability to induce death, decrease cell viability and even suppress B16F10 migration. This study is a pioneer in the antitumor evaluation of D. pubipetala and opens new lines of research for exploration. This demonstrates the promising possibility of using the species to develop new strategies for the treatment and prevention of cutaneous melanoma.