Herbal medicine is used by up to 80% of the population in developing countries. Cressa cretica L. is a popular holophytic plant and is used in folklore medicine for ailments including diabetes, ulcers, asthma, anthelmintic, stomachic, tonic and aphrodisiac purposes, enriches the blood and is useful in constipation, leprosy and urinary discharges. The plant is traditionally used in Bahrain as expectorant and antibilious agent. Scientific evidence suggests its versatile biological functions such as its antibacterial, antifungal, antitussive, anticancer with some other plants, anti-inflammatory and improving testicular function in rats. In this article, a comprehensive account of the morphology, phytochemical constituents, ethnobotany and biological activities are included in view of the recent findings of importance on the plant, C. cretica.