Plants and Phytochemicals for Huntington's Disease

Pharmacognosy Review,2013,7,14,81-91.
Published:October 2013
Type:Review Article
Authors:
Author(s) affiliations:

Sunayna Choudhary1, Puneet Kumar2, Jai Malik1

1Department of Pharmacognosy, ISF College of Pharmacy, Moga, Punjab, INDIA.

2Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, INDIA.

Abstract:

Huntington's disease (HD) is a neurodegenerative disorder characterized by progressive motor dysfunction, including chorea and dystonia, emotional disturbances, memory, and weight loss. The medium spiny neurons of striatum and cortex are mainly effected in HD. Various hypotheses, including molecular genetics, oxidative stress, excitotoxicity, metabolic dysfunction, and mitochondrial impairment have been proposed to explain the pathogenesis of neuronal dysfunction and cell death. Despite no treatment is available to fully stop the progression of the disease, there are treatments available to help control the chorea. The present review deals with brief pathophysiology of the disease, plants and phytochemicals that have shown beneficial effects against HD like symptoms. The literature for the current review was collected using various databases such as Science direct, Pubmed, Scopus, Sci-finder, Google Scholar, and Cochrane database with a defined search strategy.